Ementa: Técnicas de cultivo de células aderentes. Ensaios in vitro para células-tronco. Biointeração entre
biomateriais e células-tronco. Análises de citotoxicidade e ultraestruturais de células-tronco.
Terapia celular com células-tronco em modelos animais. Modelos para terapia dermatológica.
Modelos para terapia renal. Modelos para terapia ortopédica. Inovação tecnológica e
empreendedorismo em biotecnologia celular.
Bibliografia: BÁSICA:
LIVROS
1.Carvalho ACC, Goldenberg RCS. Células-tronco mesenquimais: Conceitos, métodos de
obtenção e aplicações. Editora Atheneu, 2012;
2.De Robertis, E.D. Bases da biologia celular e molecular. Ed. Guanabara-Koogan, Rio de
Janeiro 1993;
3.FRESHNEY, R. I. Culture of Animal Cells: A Manual of Basic Technique. 4º ed., New York:
Wiley-Liss, 2005;
ARTIGOS CIENTÍFICOS
1.Lingling Zhao, Vivian K. Lee, Seung-Schik Yoo, Guohao Dai, Xavier Intes. The integration of 3-
D cell printing and mesoscopic fluorescence molecular tomography of vascular constructs withinthick hydrogel scaffolds. Biomaterials, Volume 33, Issue 21, Pages 5325-5332;
2.Tang, Q., Piard, C., Lin, J., Nan, K., Guo, T., Caccamese, J., Fisher, J. and Chen, Y. Imaging
stem cell distribution, growth, migration, and differentiation in 3-D scaffolds for bone tissue
engineering using mesoscopic fluorescence tomography. Biotechnol. Bioeng. Accepted Author
Manuscript. doi:10.1002/bit.26452;
3.Ong,Chin Siang; Yesantharao,Pooja; Huang,Chen Yu; Mattson,Gunnar; Boktor,Joseph;
Fukunishi,Takuma; Zhang,Huaitao; Hibino,Narutoshi. 3D bioprinting using stem cells.
International Pediatric Research Foundation, Accepted article preview online 06 October 2017,
http://dx.doi.org/10.1038/pr.2017.252;
4.Hiew, Vun Vun; Simat, Siti Fatimah Binti; Teoh, Peik Lin. The Advancement of Biomaterials in
Regulating Stem Cell Fate. Stem Cell Reviews and Reports, p.1-10,
https://doi.org/10.1007/s12015-017-9764-y, 2017.
COMPLEMENTAR:
1.Argolo Neto, Napoleão M.; Del Carlo, Ricardo j.; Monteiro, Betânia s.; Nardi, Nance b.;
Chagastelles, Pedro C.; Brito, Ana Flora S.; Reis, Amanda M.S.; Silva, Laís M.C. Role of the
autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of
cutaneous wounds in diabetic mice. Pesquisa Veterinária Brasileira v. 36, p. 617-624, 2016;
2.Mao, F., Kang, J., Cai, X., Ding, N., Wu, Y., Yan, Y., Xu, W. Crosstalk between mesenchymal
stem cells and macrophages in inflammatory bowel disease and associated colorectal cancer.
Contemporary Oncology, 21(2), 9197, 2017;
3.Kang, E.-S., Kim, D.-S., Suhito, I. R., Choo, S.-S., Kim, S.-J., Song, I., & Kim, T.-H. (2017).
Guiding osteogenesis of mesenchymal stem cells using carbon-based nanomaterials. Nano
Convergence, 4(1), 2. http://doi.org/10.1186/s40580-017-0096-z;
4.Maldonado M; Luu RJ. ; Ico G; Ospina A.; Myung D.; Shih HP; Nam J. Lineage- and
developmental stage-specific mechanomodulation of induce pluripotent stem cell differentiation.
Stem Cell Research & Therapy, v. 8, doi 10.1186/s13287-017-0667-2, 2017.
5.Jayachandran Venkatesan,Sukumaran Anil,Se-Kwon Kim,Min Suk Shim. Chitosan as a vehicle
for growth factor delivery: Various preparations and their applications in bone tissue
regeneration. International Journal of Biological Macromolecules, v.104, Part B, 1383-1397,
2017;
6.Argôlo Neto, N.M.; Feitosa, MLT.; Silva, SS. ; Fernandes, PB.; Pessoa, GT.; Bezerra, DO.;
Almeida, HM.; Carvalho, YKP.; Rocha, AR.; Silva, LMC.; Carvalho, MAM. Isolation, Expansion,
Differentiation and Growth Kinetics Essay in Mesenchymal Stem Cells Culture from the Bone
Marrow of Collared Peccaries (Tayassu tajacu). Acta Scientiae Veterinariae (Online), v. 44, p. 1-
11, 2016
BASE DE DADOS RECOMENDADA: http://www.ncbi.nlm.nih.gov/pubmed